Endogenous Thrombolysis
نویسندگان
چکیده
منابع مشابه
Endogenous thrombolysis: a hidden player in acute coronary syndromes?
v ( d A o u a t c a c d ( rterial thrombosis is a major cause of morbidity and ortality worldwide. Rupture or erosion of an atheroscleotic plaque stimulates platelet adhesion and aggregation nd activation of the coagulation cascade, which result in hrombus formation. The fate of an evolving thrombus is argely determined by the balance between proaggregatory nd procoagulant factors, on the one h...
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The influence of dietary bacillus natto productive protein (BNPP) on endogenous thrombolysis was investigated in the rat. Animals were given a standard feed for 14 weeks, to which 0.2 or 1% BNPP was added. Thrombolysis was evaluated using an He-Ne laser-induced thrombosis model in mesenteric microvessels. Changes in thrombus volume, reflecting thrombolysis, decreased to 82% of the initial value...
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The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA) released from endothelial cells. In man, sympathomimetic drugs increase the systemic concentration of t-PA. It is therefore of interest to investigate whether cardiac sympathetic activation can induce a local t-PA release, which could counteract intracoronary clot formation. Th...
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We have previously confirmed, using a rat mesenteric arteriole thrombolysis model, that thrombin inhibition induces endogenous thrombolysis in vivo. In addition, we have shown that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the down regulation of endogenous thrombolysis. However, the mechanism of endogenous thrombolysis or spontaneous plasmin generation in vivo remains u...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2010.01.034